It has long been known in science that reactive oxygen species (ROS) are associated with ageing and human diseases (cardiovascular disease, Alzheimer's, neurodegenerative diseases and cancer).
ROS are formed in biological processes, add up to a product of oxidative metabolism and play a crucial role as signalling molecules.
Our laboratory has now decided to focus on the study of hydrogen peroxide (H2O2)and develop fluorescent probes for its detection.
Our goal is to obtain a highly sensitive, photostable probe that is only selective to H2O2 for detection of endogenous hydrogen peroxide in living cancer cells.
Planned outcome: a practical probe to detect and visualize even small amounts of endogenously generated H2O2, which is very important for the study of H2O2-related cell signalling and human diseases.
The Chemical Synthesis Laboratory